Fig. 7.

Silencing of MTSS1 reduced trabecular bone mass in mice. qRT-PCR (A) and Western blotting (B) were done to verify the silencing of MTSS1 mRNA in the BMSCs isolated 48 h after in vivo transfection of MTSS1 siRNA. Three-dimensional reconstruction of μCT images are shown (C) and histomorphometric parameters were measured (D–G) in the mice 4 weeks after in vivo transfection. Data are mean ± SD. A: n = 3; D–G, n = 6. Student’s t test was conducted. *p < 0.05 vs. Control siRNA