Fig. 7.

Mathematical simulation of the effect of misaligned insulin and glucocorticoid signaling on the clock in the exocrine pancreas. The effect of a concurrent (# *; ad libitum conditions) or b alternating (rRF conditions) timing of insulin (*) and corticosterone (#) signals (as observed in daily profiles of hormone levels) on phase and amplitude of sine curve representing responses of PER2-driven bioluminescence rhythm in the exocrine pancreas. Resulting curves are accompanied by the baseline curve for reference (dashed line). For more details, see “Materials and methods” section