Fig. 8.

Schematic summary of the results. Feeding aligned with activity status (as occurs in rats under ad libitum conditions) is associated with a coupling between the peaks in insulin and corticosterone levels and the phases of the clocks in the endocrine and exocrine parts of the pancreas. Misaligned feeding uncouples the hormone peaks, causing a discordance between these normally synchronous clocks of these two functionally distinct parts of the pancreas and severely compromising the clock and function of the exocrine pancreas