Fig. 2.

Gene expression of sensory nerves in skin. a The top two principal components for the samples in the cohort. b Volcano plot detecting proteins by FC and P value. c Venn diagram showing the overlap between DEGs. d List of DEGs in different functions of sensory nerve. e Up-regulated DEGs and down-regulated DEGs. f INA gene expression at baseline, 15 days and 43 days after treatment with control substance, 140 mg, 350 mg and 700 mg doses of Brodalumab. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, one-way ANOVA. (Dataset from GSE121212)