Fig. 3.

Schematic of hypoxia-driven splicing events in several hallmarks of cancer. The splicing patterns shown by solid blue lines represent hypoxia-specific splicing, whereas the grey lines represent normoxia-specific events. Hx above the blue arrow indicates the hypoxia-induced transcripts. a Examples of hypoxia-specific AS events contributing to sustaining proliferative signaling. b Examples of hypoxia-specific AS events contributing to metastasis. c Examples of hypoxia-specific AS events contributing to angiogenesis. d Examples of hypoxia-specific AS events contributing to metabolic changes. e Examples of hypoxia-specific AS events contributing to immune evasion. f Examples of hypoxia-specific AS events contributing to apoptosis avoidance. g Examples of hypoxia-specific AS events contributing to replicative immortality