Fig. 4.

Schematic of hypoxia-driven splicing events in neurological disorders and cardiovascular defects. The splicing patterns shown by blue lines represent hypoxia-specific splicing, whereas the grey lines represent normoxia-specific events. a Examples of hypoxia-specific AS events contributing to neurological disorders like Spinal muscular atrophy, Tauopathies, Alzheimer's Disease, and Hypoxic-ischemic encephalopathy. (Among EAAT2 splice variants, mEAAT2/5UT4 and mEAAT2/5UT5 are modulated by hypoxia). b Examples of hypoxia-specific AS events contributing to cardiovascular disease