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. 2021 Jul 28;78(17-18):6143–6160. doi: 10.1007/s00018-021-03905-8

Table 2.

Disease modifiers identified in Drosophila SOD1-ALS models

Disease modifier Fly transgenic construct Phenotypic rescue Refs.
Withania somnifera extracts D42-Gal4 > hSOD1G85R Motor behavior, lifespan [104]
Urate D42-Gal4 > hSOD1G85R Motor behavior, oxidative stress, lifespan [106]
α-lipoic acid D42-Gal4 > hSOD1G85R Motor behavior, lifespan [107]
Fisetin D42-Gal4 > hSOD1G85R Motor behavior, SOD1 aggregates [108]
γ-oryzanol D42-Gal4 > hSOD1G85R Motor behavior, oxidative stress, lifespan [109]