Fig. 3.

The role of TFs in derivation of erythroid and megakaryocytes lineages from the multipotent MEP cells. Differential expression of 5 TFs EKLF, GATA1, GATA2, FLI1, and RUNX1 determines the fate of HSC-derived MEP cells to become either erythroid or megakaryocytes. Lower FLI1 expression favors erythroid differentiation through negative regulation of GATA1 and EKLF, in coordination with erythropoietin (EPO). Higher and phosphorylated FLI1* promotes megakaryocytic differentiation through upregulation of RUNX, downregulation of EKLF and GATA1, in coordination with thrombopoietin (TPO)