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Chemotherapy drugs affect ribosome biogenesis at multiple levels. Ribosome biogenesis supports cancer cell growth and proliferation, hence, it is a common target of many chemotherapy drugs. Chemotherapy drugs may affect ribosomal DNA transcription, Pol I activy, pre-rRNA processing and maturation into mature ribosomes. Some drugs may affect translation of ribosomal and growth-related proteins, also affecting ribosome biogenesis
