Fig. 1.

Overview of the complex interactions between tumor cells and immune cells and the metabolic characteristics of these cells. During tumorigenesis and malignant progression, a complex intercellular interaction network is established between tumor-infiltrated immune cells and tumor cells that improves and maintains the immunosuppressive microenvironment and promotes immune escape. Black arrow recruit or promote, Pink T-line inhibit, Red up arrow upregulate, Red down arrow downregulate, TME tumor microenvironment, TAM tumor-associated macrophage, Treg regulatory T cell, DC dendritic cell, MDSC myeloid-derived suppressor cell