Fig. 3.

Overview of mitochondrial dynamics. a Mitochondrial fission is mediated by ER-mito interplay involving an initial OMM constriction via INF2-mediated ACT polymerization and IMM fission by MTFP1. DNM1L is then recruited to OMM adaptor proteins to complete the final constriction and scission of the mitochondria. b Mitochondrial fusion is mediated by the interaction of MFN1/2 found on the OMM, followed by OPA1 interaction with cardiolipin on the IMM. These events can take place at ER-mito contact sites