Fig. 2.

Upregulation of GRP78 in macrophages upon M2 polarization. A Representative flow cytometry image of M2 macrophages in each group is shown. B Representative flow cytometry image of M1 macrophages in each group is shown in each group. C The proportions of M2 macrophages in each group were determined by flow cytometry. N = 6. D The proportions of M1 macrophages in each group were determined by flow cytometry. N = 6. E The expression of GRP78 in human lung adenocarcinoma (LUAD) tumour samples and normal tissues in TCGA database. F The expression of GRP78 in human lung squamous cell carcinoma (LUSC) tumour samples and normal tissues in TCGA database. G The expression of GRP78 and CD206 in human lung tumour samples and normal tissues by IHC staining. All results are representative of three independent experiments. Error bars represent the mean ± SD. p values were determined by one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test (C, D). ***p < 0.001, **p < 0.01, *p < 0.05