Table 1.

Summary of findings

Does the food deprivation induced activation of the PVHCRF neurons require		Observations
	Key experimental groups in food-deprived conditions	PVHCRF neuron activation	Plasma corticosterone
ARC integrity?	ARH-ablated mice as compared to ARH-intact mice	↓	⇊
GHSR signaling?	Genetic approach GHSR-deficient mice as compared to WT mice	⇊	⇊
	Pharmacological approach K-(D-1-Nal)-FwLL-NH2-treated mice as compared to Vehicle-treated mice	↓	NC
ghrelin-evoked GHSR signaling?	Genetic approach Ghrelin-KO mice as compared to WT mice	NC	-
	Pharmacological approach Anti-ghrelin-treated mice as compared to Vehicle-treated mice	NC	-
A fall of LEAP2 plasma levels?	Pharmacological approach LEAP2(1-12)-treated mice as compared to Vehicle-treated mice	↓	NC

↓, decrease; ⇊, strong decrease;NC No change