Fig. 4.

Mechanisms of SIRT1-mediated signaling pathways involved in DOX-induced cardiotoxicity. Diagram showing proposed downstream targets of SIRT1 and their related effects implicated in DOX-induced cardiotoxicity. SIRT1 Sirtuin 1, DOX doxorubicin, PGC-1α peroxisome proliferator-activated receptor gamma coactivator-1 alpha, NRF-1 nuclear respiratory factor 1, TFAM mitochondrial transcription factor A, COXIV cytochrome c oxidase IV, ∆Ψm mitochondrial membrane potential, ROS reactive oxygen species, VDAC voltage-dependent anion channel, Cyt C cytochrome c, LKB1 liver kinase B1, AMPK AMP-activated protein kinase, NF-κB nuclear factor kappa B, TNF-α tumor necrosis factor-alpha, IL interleukin, NRF2 nuclear factor erythroid 2-related factor 2, NQO1 NAD(P)H quinone dehydrogenase 1, CAT catalase, HO-1 heme oxygenase-1, p53 tumor protein p53, Bcl-2 B-cell lymphoma 2, Bax Bcl-2-associated X protein, MAPK mitogen-activated protein kinase, FOXO1 forkhead box O 1, TGF-β transforming growth factor-beta, SMAD3 mothers against decapentaplegic homolog 3, NLRP3 NOD-like receptor family pyrin domain-containing protein 3