Fig. 8.

N6-Methyladenosine METTL3 maintains the expression of PARP1. A Representative images of PARP1 and METTL3 levels stained by immunofluorescence of organoids of METTL3 overexpression, PARP1 overexpression, METTL3 overexpression and PARP1 overexpression in organoid and tumor. The scale represents 20 μm of organoid. The scale represents 200 μm of tumor. B Proportion of METTL3 + cells in organoids in (A). C Proportion of PARP1 + cells in organoids in (A). D Proportion of METTL3 + cells in tumor in (A). E Proportion of PARP1 + cells in tumor in (D). * p < 0.05, ** p < 0.01, *** p < 0.001