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. 2021 Jan 3;78(6):2683–2708. doi: 10.1007/s00018-020-03725-2

Table 4.

Summary of regulatory CRISPR/Cas systems

Type of system Split-Cas9 Light-inducible Destabilizing domain NS3 domain
Intein-inducible Rapamycin-inducible Photoactivatable
In vivo studies [259] n/a n/a [178] [260] n/a
Delivery vehicle Viral-based delivery: AAV n/a n/a DNA-based delivery: electroporation DNA-based delivery: tail vein hydrodynamic injection n/a