Fig. 1.

Overview of the regulatory network of HSC quiescence. HSC quiescence is regulated by multiple factors, and intrinsically, cell cycle-associated factors and cell metabolism directly govern HSC quiescence. Niche cells, niche-secreted factors, kinases, transcription factors, and epigenetic factors comprise a complicated network. The network transduces multiple signaling and primarily affects cell cycling and cell metabolism, eventually preserving HSC quiescence to sustain long-term maintenance of HSCs and life-long hematopoiesis