Fig. 4.

Recruitment of TRIMs at distinct steps of the pathway. Several TRIMs are recruited at different  steps of the TNF-α-induced NF-κB pathway. TRIMs either share the same substrate or distinct target and show functional synergy and antagonism in regulation of the TNF-α-induced NF-κB pathway. TRIM38 is induced by TNF-α, hence act as a feedback negative regulator of the TNF-α-induced NF-κB pathway. PTM of TRIM9 and 27 by phosphorylation provides an additional layer of control over the TRIM-mediated regulation TNF-α-induced NF-κB pathway