Table 4.
WHO priority list for research and development of new antibiotics for antibiotic-resistant bacteria [126] and corresponding taxonomy classification of the pathogens
| Diseases | Pathogen | Taxonomy group | Available high-res FOF1 from the same group (PDB IDs) |
|---|---|---|---|
| Bacterial pathogens | |||
| Tuberculosis | Mycobacterium tuberculosis | Bacteria; terrabacteria group; actinobacteria | Mycobacterium smegmatis (7JG5; 7JG6; 7JG7; 7JG8; 7JG9; 7JGA; 7JGB; 7JGC) |
| Pneumonia; bloodstream infections; meningitis; wound and surgical site infections, including necrotizing fasciitis; urinary tract infections | Acinetobacter baumannii | Bacteria; proteobacteria; gammaproteobacteria | E. coli (6OQR; 6OQS; 6OQT; 6OQU; 6PQV; 6WNQ; 6OQV; 6OQW; 6WNR; 6VWK) |
| Pneumonia; septic shock; urinary tract infection; gastrointestinal infection; skin and soft tissue infections | Pseudomonas aeruginosa | ||
| Plague; salmonellosis | Enterobacteriaceae | ||
| Salmonellosis | Salmonella sp. | ||
| Pneumonia; meningitis; epiglottitis | Haemophilus influenzae | ||
| Shigellosis | Shigella sp. | ||
| Enterococcal infections [127] | Enterococcus faecium | Bacteria; terrabacteria group; firmicutes | Bacillus PS3 (recombinant) 6N30; 6N2Z; 6N2Y |
| Abscesses; sinusitis; food poisoning | Staphylococcus aureus | ||
| Meningitis; otitis media; sinusitis; community-acquired; pneumonia | Streptococcus pneumoniae | ||
| Gastritis; duodenitis; stomach cancer | Helicobacter pylori | Bacteria; proteobacteria; delta/epsilon subdivisions; epsilonproteobacteria | N/A |
| Campylobacteriosis | Campylobacter sp. | ||
| Gonorrhea | Neisseria gonorrhoeae | Bacteria; proteobacteria; betaproteobacteria | N/A |
| Eukaryotic pathogens | |||
| African trypanosomiasis | Trypanosoma brucei | Eukaryota; discoba | Euglena gracilis (6TDU; 6TE0; 6TDY; 6TDZ) |
| Visceral leishmaniasis | Leishmania donovani | ||
| Babesiosis or piroplasmosis | Babesia spp. | Eukaryota; Sar |
Tetrahymena thermophile (6YNV; 6YNW; 6YNX; 6YNY; 6YNZ; 6YO0) Toxoplasma gondii (6TMH; 6TMG; 6TMJ; 6TMI; 6TML; 6TMK) |
| Toxoplasmosis | Toxoplasma gondii | ||
| Cryptosporidiosis | Cryptosporidium spp. | ||
| Malaria | Plasmodium spp. | ||
| Balantidiasis | Balantidium coli | ||
| Giardiasis | Giardia lamblia | Eukaryota; metamonada | N/A |
| Trichomoniasis | Trichomonas vaginalis | ||
| Amoebiasis | Entamoeba histolytica | Eukaryota; amoebozoa | N/A |