Fig. 6.

PUM1-mediated translational control of cell cycle genes contributed to ovarian cancer progression and prognosis. A Oncomine database analysis of the expression of PUM1 mRNA in normal ovary tissue and ovarian carcinoma tissue. The P value was shown. B Overall survival curves with low-medium or high expression of PUM1 transcripts were analyzed of 303 ovarian cancer patients (The Kaplan–Meier survival plot from UALCAN using TCGA ovarian cancer data set). C Human PUM1 protein expression in ovarian cancer compared with normal controls from CPTAC (Clinical Proteomic Tumor Analysis Consortium) based on UALCAN database. The P valued was shown. D Survival curve based on the expression of PUM1 protein in ovarian cancer patients from the Human Protein Atlas web-portal (log-rank test P value = 0.024). E CDKN1B and F WEE1 protein expression was significantly down-regulated in ovarian cancer in compared to normal tissues from the CPTAC database