Fig. 1.

LAMC2 is highly upregulated and associated with worse survival in patients with PDAC. A LAMC2 transcript is overexpressed in PDAC tumor specimens compared to normal or adjacent non-cancerous pancreatic samples in the microarray data (GSE15471, GSE28735, and GSE62125). Statistical significance was calculated using GraphPad Prism (***P-value < 0.0001; two-tailed t-test). B RNA sequencing data analysis displayed higher LAMC2 transcript in PDAC and other human malignancies in TCGA Pan-Cancer datasets. C, D Kaplan–Meier plots analysis displayed elevated levels of LAMC2 transcripts were linked with overall (P-value < 0.0001) and disease-free survival (P-value < 0.012) in the patients with PDAC (TCGA data). Statistical significance was calculated using the Log-rank test