Fig. 4.

Inhibition of LAMC2 suppressed migration and invasion of PDAC cells through Epithelial-Mesenchymal Transition (EMT). A, B LAMC2 knockdown inhibited migration and invasion of HPAC, Panc0327, and Panc0203 cells. Results represent mean ± SD; n = 3. **P-value < 0.001; ***P-value < 0.0001; two-tailed t-test. C, D Western blotting and densitometry data displayed significantly decreased protein expression of ZEB1, N-cadherin, vimentin, and increased expression of E-cadherin in LAMC2 depleted PDAC cells