Table 1.
The classification of RTK subfamilies
| Class | Subfamily name | Members |
|---|---|---|
| 1 | EGFR | EGFR, ERBB2/3/4 |
| 2 | Ins | INSR IGFR |
| 3 | PDGF | PDGFRα, PDGFRβ, M-CSFR, KIT, FLT3L |
| 4 | VEGF | VEGFR1/2/3 |
| 5 | FGFs | FGFR1/2/3/4 |
| 6 | CCK | CCK4 |
| 7 | NGF | TRKA, TRKB, TRKC |
| 8 | HGF | RON, MET |
| 9 | Eph | EPHA1-6, EPHB1-6 |
| 10 | AXL | AXL, MER, TYRO3 |
| 11 | TIE | TIE, TEK |
| 12 | RYK | RYK |
| 13 | DDRs | DDR1/2 |
| 14 | RET | RET |
| 15 | ROS | ROS |
| 16 | LTK | ALK, LTK |
| 17 | ROR | ROR1/2 |
| 18 | MuSK | MuSK |
| 19 | LMR | AATYK1/2/3 |
| 20 | Undetermined | Undetermined |
EGFR epidermal growth factor receptor; InsR insulin receptor; PDGFR platelet-derived growth factor receptor; VEGFR vascular endothelial growth factor receptor; FGFR fibroblast growth factor receptor; CCK colon carcinoma kinase; NGFR nerve growth factor receptor; HGFR hepatocyte growth factor receptor; EphR ephrin receptor; Axl a Tyro3 PTK; TIE tyrosine kinase receptor in endothelial cells; RYK receptor related to tyrosine kinases; DDR discoidin domain receptor; Ret rearranged during transfection; ROS RPTK expressed in some epithelial cell types; LTK leukocyte tyrosine kinase; ROR receptor orphan; MuSK muscle-specific kinase; LMR lemur