Fig. 3.

BCL2L13 plays important roles in a variety of physiological and pathological processes. a Constitutive expressing in human embryo, BCL2L13 promotes embryonic development, and maintains organismal homeostasis by its pro-apoptotic ability. b High content of BCL2L13 arising in skeletal muscle after exercise could be beneficial for ATP supply. c BCL2L13 adjusts stomach carcinogenesis conform to certain pathological condition. d SidF from Legionella pneumophila is used to neutralize BNIP3 and BCL2L13 in lung macrophages, resulting in expanding of bacterial reproduction. e Lower BCL2L13 retards age-associated degenerative diseases, like OA. f Elevated BCL2L13 caused by cerebral I/R injury are inclined to formidable brain damage in mice