Fig. 6.

Conformational changes in SARS-CoV-2 S protein mutants and their interactions with hACE2. Representation of conformational changes in the tertiary structure of S protein mediated by S477N, T478K and S494P mutation. PDB id: 6LZG was used for wild-type protein while mutant types were prepared by PyMOL [156] and energy minimized for further studies. Wild type SARS-CoV-2 residues are indicated in orange and mutated residues are depicted in yellow. Mutated residues are marked in red font. hACE2 is represented in green and magenta