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Schematic diagram for the pro-metastatic role of Sec62 in GC. Schematic diagram of the role of Sec62 in GC metastasis. Sec62 activation of autophagy may involve two pathways, namely, the UPR-related PERK/ATF4 pathway and binding of LC3II during UPR recovery involving FIP200/Beclin-1/Atg5 upregulation. Autophagy subsequently promotes GC metastasis by regulating the TIMP-1 and MMP2/9 balance
