Table 2.

Univariable and multivariable analysis of clinicopathological factors for overall survival

Variables	Univariable		Multivariable
	HR (95% CI)	P value	HR (95% CI)	P value
Gender (male/female)	1.153(0.768–1.890)	0.751
Age (years, < 50 vs ≥ 50)	2.939(1.419–5.863)	0.008	3.217(1.305–6.921)	0.005
Smoke (no/yes)	2.091(1.135–4.589)	0.027	2.109(1.056–4.762)	0.018
Alcoholism(no/yes)	1.382(0.639–2.531)	0. 598
Metastasis (no/yes)	3.409 (1.439–8.757)	0.010	3.602 (1.368–9.583)	0.020
Tumor size (cm, ≤ 5 vs. > 5)	2.896 (1.581–6.537)	0.002
Microvascular invasion (no/yes)	2.758 (1.311–5.278)	0.010
TNM stage (I vs. II & III)	2.093 (1.596–3.769)	0.001
Sec62 (low vs high)	4.751 (2.068–11.089)	0.000	5.016 (2.109–12.649)	0.000

TNM tumor, node, metastasis