Figure 6.

WD40 proteins detected in a PSI-BLAST simulated checkpoint search based on a HMM of UV-DDB-127 repeats. One representative sequence is shown for each of 32 distinct protein families that were detected (E value < 0.001) in a search of the NCBI non-redundant database. (The criterion for clustering any two sequences into the same family was a pairwise gapped BLAST score with an E value < 1 × 10^–10.) All of the families detected are known to contain WD40 repeats except for two small families of uncharacterized proteins that (aside from our analysis) appear to be unrelated to other proteins. Sequences with descriptions in gray harbor marginally significant internal repeats (with 0.001 < E value < 0.01, as indicated in the far right column). Additional WD40 protein families were detected in the search but are not shown because the corresponding sequences all harbor clearly significant internal repeats (E values < 0.001), which may significantly inflate their computed statistical significance (see Materials and Methods).