Table 6.
Correlation between different regulatory CD4+ T cell subsets and clinical parameters
| Expression (%) | αCD3/CD28 | MBP/IL-2 | ||||||
|---|---|---|---|---|---|---|---|---|
| EDSS | BDI | EDSS | BDI | |||||
| r | p | r | p | r | p | r | p | |
| CD39+CD4+ T cells | − 0.4187 | 0.0944 | 0.0953 | 0.7133 | − 0.3938 | 0.1628 | − 0.0804 | 0.7825 |
| CTLA-4+IL-10− | 0.0684 | 0.8086 | − 0.533 | 0.0187 | − 0.1605 | 0.5798 | − 0.5176 | 0.0603 |
| CTLA-4+IL-10+ | − 0.2696 | 0.3278 | − 0.2316 | 0.4034 | 0.1627 | 0.5176 | − 0.0374 | 0.8988 |
| CD39+CD25+CD4+ T cells | − 0.3974 | 0.1274 | 0.1939 | 0.4858 | − 0.6579 | 0.0129 | 0.033 | 0.9124 |
| CTLA-4+IL-10− | − 0.2013 | 0.4720 | − 0.5297 | 0.0238 | − 0.0361 | 0.9038 | − 0.5624 | 0.0151 |
| CTLA-4+IL-10+ | − 0.2095 | 0.4497 | − 0.1436 | 0.6074 | 0.0091 | 0.9765 | 0.0601 | 0.8369 |
Bold values are statistically significant (p < 0.05)
The percentage of different CD39+Treg cells was determined by flow cytometry after PBMC cell cultures activation with anti-CD3/anti-CD28 beads (αCD3/CD28) or MBP/IL-2
EDSS expanded disability status scale, BDI beck depression inventory (BDI)