Fig. 12.

The prospective pathomechanism contributing to the FD-induced hepatomegaly. FD triggers necroptosis and Hippo/YAP pathway, leading to enlarged hepatocyte and hepatomegaly. FD also caused inflammation and macrophages infiltration in liver, which act as an additional route to activate necroptotic pathway and YAP signaling via increasing TNFα activity and mmp13, the metalloprotease mediating TNFα cleavage and activation. The FD-induced inflammation and necroptosis convene a dialog of positive feedback loops, further deteriorating hepatomegaly