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CHIP modulates cell proliferation and migration via HMGB1. A–D 11Z cells were transfected with vector, Flag-CHIP, HA-HMGB1, and Flag-CHIP + HA-HMGB1, respectively. Forty-eight hours later, wounding healing assay, transwell invasion assay, cell proliferation assay, and colony formation assay were performed (scale bar, 50 µm). (All data represent mean ± SEM. One-way ANOVA was used for data analysis. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)
