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. Author manuscript; available in PMC: 2024 May 6.
Published in final edited form as: J Med Chem. 2023 Aug 16;66(16):11027–11039. doi: 10.1021/acs.jmedchem.3c01178

Table 1.

5-HT Receptor Classification.a

Family Potential Type Mechanism of Action
5-HT1 Inhibitory Gi/Go protein-coupled Decrease intracellular concentrations of cAMP
5-HT2 Excitatory Gq11 protein-coupled Increase intracellular concentrations of IP3, DAG, and calcium
5-HT3 Excitatory Ligand-gated ion channel Depolarization of plasma membrane
5-HT4 Excitatory Gs protein-coupled Increase intracellular concentrations of cAMP
5-HT5 Inhibitory Gi/Go protein-coupled Decrease intracellular concentrations of cAMP
5-HT6 Excitatory Gs protein-coupled Increase intracellular concentrations of cAMP
5-HT7 Excitatory Gs protein-coupled Decrease intracellular concentrations of cAMP
a.

Adapted from Reference 4.