Table 2. Pairwise Wilcoxon rank-sum test for each antibiotic resistance class detected in the gut of preschool children.

A		Antibiotic classes
Groups	Treatment	Aminoglycosides	Cationic antimicrobial peptides	Macrolides	Metronidazole	Multi drug resistance	Tetracyclines	Trimethoprim	Beta-lactams
1 vs. 2	AA-AA-AA-AA-A vs. PP-PP-AA-AA-A	0.218	0.918	0.187	0.255	0.945	0.140	0.112	0.408
1 vs. 3	AA-AA-AA-AA-A vs. AA-AA-AA-PP-P	0.379	0.935	0.063	0.957	0.291	0.908	0.690	0.957
1 vs. 4	AA-AA-AA-AA-A vs. PP-PP-AA-PP-P	0.218	0.791	0.014	0.884	0.848	0.927	0.730	0.957
2 vs. 3	PP-PP-AA-AA-A vs. AA-AA-AA-PP-P	0.055	0.980	0.003	0.689	0.530	0.157	0.690	0.515
2 vs. 4	PP-PP-AA-AA-A vs. PP-PP-AA-PP-P	0.011	0.973	< 0.001	0.840	0.945	0.193	0.611	0.508
3 vs. 4	AA-AA-AA-PP-P vs. PP-PP-AA-PP-P	0.533	0.980	0.517	0.957	0.652	0.908	0.927	0.959
B
	Benjamini–Hochberg*	0.066	0.791	NA	0.350	0.350	0.280	0.280	NA

(A) Because for each antibiotic outcome, 4 groups imply 6 different pairwise comparisons, min-P adjustment procedure was performed with 100,000 permutations for each antibiotic resistance category. The P-values derived from the min-P procedure that were prespecified in the Statistical Analysis Plan are presented in this table. (B) Following the analysis within each antibiotic class based on the min-P procedure, a further Benjamini–Hochberg procedure was performed with an FDR prespecified at <0.05 to adjust for multiple antibiotic classes being compared as prespecified, and these values are presented in this table. Abbreviations: A, azithromycin; P, placebo.

*Adjustment of SMALLEST p-value for each min-P Wilcoxon.