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. 2024 Apr 17;6(3):fcae141. doi: 10.1093/braincomms/fcae141

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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GCIs morphometry and α-syn seeding amplification assay. (A) The mean size of α-syn-ir GCIs is similar between Aβ-predominant ADNC-MSA and non-Aβ-predominant ADNC-MSA cases in the putamen and cerebellum white matter (n = 4 versus 12). Mann–Whitney U test is applied for the statistics. (B) α-syn seeding amplification assay demonstrates that two cases (MSA 1, Aβ-predominant ADNC-MSA; MSA 5, intermediate form Aβ-predominant) exhibit distinctive seeding kinetics from others (2 Aβ-predominant ADNC-MSA and 4 non-Aβ-predominant ADNC-MSA). ns, not significant; RFU, relative fluorescent unit; WM, white matter.