Table 3.
Aβ-peptide molecular signatures between MSA cases with Aβ-predominant ADNC and Alzheimer’s disease cases
| MSA 1 | MSA 2 | MSA 3 | MSA 4 | AD1 | AD2 | AD3 | AD4 | P-value | |
|---|---|---|---|---|---|---|---|---|---|
| Thal Aβ phase | 5 | 5 | 5 | 5 | 4 | 5 | 5 | 5 | n.s. |
| Braak NFT stage | II | I | II | I–II | VI | VI | VI | VI | <0.001 |
| CERAD | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 3 | <0.01 |
| Aβ immunoreactivity | |||||||||
| Temporal cortex | |||||||||
| Pan-Aβ (6F3D) | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | n.s. |
| Cored plaque | 2 | 2 | 2 | 2 | 4 | 3 | 3 | 3 | <0.05 |
| Aβ40 | |||||||||
| Diffuse plaque | 3 | 2 | 4 | 3 | 3 | 4 | 4 | 3 | n.s. |
| Cored plaque | 2 | 0 | 1 | 1 | 3 | 3 | 3 | 3 | <0.05 |
| Aβ42 | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | n.s. |
| Cored plaque | 2 | 2 | 2 | 2 | 4 | 4 | 3 | 3 | <0.05 |
| Aβ43 | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | n.s. |
| Cored plaque | 2 | 1 | 2 | 2 | 4 | 4 | 3 | 3 | <0.05 |
| AβNp3E | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | n.s. |
| Cored plaque | 2 | 2 | 2 | 2 | 4 | 3 | 3 | 3 | <0.05 |
| AβpSer8 | |||||||||
| Diffuse plaque | 3 | 3 | 3 | 3 | 4 | 4 | 3 | 2 | n.s. |
| Cored plaque | 2 | 1 | 2 | 1 | 3 | 2 | 2 | 2 | n.s. |
| Striatum | |||||||||
| Pan-Aβ (6F3D) | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | n.s. |
| Cored plaque | 0 | 0 | 1 | 0 | 2 | 3 | 2 | 1 | <0.05 |
| Aβ40 | |||||||||
| Diffuse plaque | 0 | 0 | 1 | 0 | 2 | 3 | 3 | 2 | <0.05 |
| Cored plaque | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 0 | <0.05 |
| Aβ42 | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | n.s. |
| Cored plaque | 0 | 0 | 1 | 0 | 2 | 3 | 2 | 1 | <0.05 |
| Aβ43 | |||||||||
| Diffuse plaque | 3 | 3 | 3 | 3 | 4 | 4 | 4 | 4 | <0.01 |
| Cored plaque | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 0 | <0.05 |
| AβNp3E | |||||||||
| Diffuse plaque | 4 | 4 | 4 | 4 | 4 | 3 | 4 | 4 | n.s. |
| Cored plaque | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 1 | <0.05 |
| AβpSer8 | |||||||||
| Diffuse plaque | 3 | 2 | 3 | 1 | 3 | 3 | 4 | 1 | n.s. |
| Cored plaque | 0 | 0 | 1 | 0 | 2 | 3 | 0 | 0 | n.s. |
Mann–Whitney U test is applied for statistics. The values highlighted in bold indicate statistical significance.
AβNp3E, pyroglutamate Aβ at the third glutamic acid; AβpSer8, phosphorylated-Aβ at the eighth serine; n.s., not significant.