Skip to main content
. 2024 Apr 24;20(4):e1011800. doi: 10.1371/journal.pcbi.1011800

Fig 15. The effect on CaMKII phosphorylation of trapping CaMKII and CaM inside the PSD of a dendritic spine head.

Fig 15

Three different conditions were simulated within a compartment representing a dendritic spine head containing a subcompartment representing a postsynaptic density (PSD) shown in panel D. (A) All molecules are homogeneously distributed throughout the entire spine head. The PSD is made to be transparent to the diffusion of all molecules. (B) The PSD is made to be reflective to CaMKII and CaM, but transparent to calcium ions and PP1. All the molecules are homogeneously distributed throughout both compartments. (C) The PSD is made to be reflective to CaMKII and CaM and 50% of the CaMKII molecules are trapped inside the PSD, while the rest of the molecules are distributed homogeneously throughout the remainder of the spine head. D) Diagram of the spine head compartment 0.5 x 0.5 x 0.5 um in size containing the PSD subcompartment 0.05 x 0.4 x 0.4 um in size. The plots show an average of 60 runs, lighter-shaded bands represent the standard error of the mean.