(A) ELISA of serum SARS-CoV-2 spike after immunizing the mice with exosomes from controls, and vaccinated individuals at D15, D21 and D30. (B) EliSPOT for cytokine development (IL10, IL17, TNFα and IFNγ) in splenocytes in response to SARS-CoV-2 spike antigen after immunizing the mice with exosomes from controls, and vaccinated individuals at D30. Graphs are represented as bar graphs with mean and SD (vertical bar line). The mice experiments were performed at least 3 times independently and in each group there were n=3 or n=5 animals.