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. 2024 Mar 28;10(2):e200144. doi: 10.1212/NXG.0000000000200144

Figure 4. Biological Functional and Disease Pathways Targeted by DEmiRs Target Genes of BAC-ATXN2[Q72] Mouse Data Set.

Figure 4

(A, B) The vertical axis shows the names of the pathways indicated by bars in the chart. The horizontal axis represents the bar length corresponding to the -log(p value) (Fisher exact test p value) for the molecules assigned to each pathway. A higher -Log(p value) indicates a pathway that is significantly targeted by DEmiR target genes of BAC-ATXN2[Q72] mouse data set (upregulated and downregulated). (A) The orange, blue, and gray bars in the chart indicate predicted pathway activation, predicted inhibition, or predicted no activity by BAC-ATXN2[Q72] target DEGs (both the direction), denoted by z score. Positive Z score: pathway activation (orange), negative Z score: pathway inhibition (blue), and zero Z score: predicted no activity (gray). DEmiRs = differentially expressed miRNAs.