Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 4;38(5):1164–1168. doi: 10.1038/s41375-024-02239-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Study design and analysis flow. b Cell type composition of each cellular neighborhood cluster (CNC). The CNCs are ordered by increasing tumor content. c Aggregate spatial context networks across all samples in Cohort A. Each CNC is represented as a colored node, with node sizes proportional to the total number of CNCs in the samples. Edges between two CNCs are shown if >10% of CNs within the two CNCs were in close proximity. Edge thickness (weight) is proportional to this percentage of close proximity between pairs of CNCs. Self-edges are not included for visual clarity. d Spatial context network edge weights (fraction of CNs within each CNC in close proximity) between tumor-rich CNs and all other CNs, for each sample in Cohort A. This is a quantified depiction of the edge weights shown in c, between tumor-rich CNs and all other CNs. e Relative expression of functional markers across all eight CNCs, for Cohort A. CNCs are ranked based on immune cell abundance and labeled as immune-rich and immune-sparse. f The expression of PD-L1 or IDO-1 on tumor cells within each sample. p values from Wilcoxon paired test.