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. 2024 May 6;15:3786. doi: 10.1038/s41467-024-48244-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Venn diagram showing the sharing between different types of cis-QTLs. In total, 16,599 independent top cis-QTL signals for 10,804 genes were detected. B Enrichment within annotated genomic regions (represented as a blue-red heatmap) for different types of cis-QTLs and shared cis-QTLs relative to cis-QTLs not contained in or shared with that group of cis-QTLs. Asterisks indicate a significant enrichment (*, p < 0.05, **, p < 0.001, ***, p < 0.00001, two-sided Fisher’s exact test). The overall overlap for all cis-QTLs with different genomic regions is indicated in grayscale. cCRE: candidate cis-regulatory element, UTR: untranslated region, CDS: coding sequence. C Similar as B, but for enrichment in overlap with specific molecular QTLs identified for LCLs. D Similar as B, but for enrichment within genes harbouring certain binding sites determined in LCLs, considering top cis-QTLs located within genes.