Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 6;15:3786. doi: 10.1038/s41467-024-48244-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — A Number of top cis-QTLs colocalizing with GWAS variants (filled bars) of tested QTLs (full bars) for different QTL types. B Number of GWAS variants colocalizing with top cis-QTLs (filled bars) of tested GWAS variants (full bars) for colocalization with exQTL and all QTL types. P value was calculated using two-sided Fisher’s exact test. C Percentage of colocalizing GWAS variants (x-axis) and log2 ratio of GWAS variants colocalizing with exQTL to those colocalizing with inQTLs or ex-inQTLs (y-axis), for 78 GWAS traits with at least 25 colocalizations. GWAS traits with extreme values are labelled, and the number of colocalizing GWAS variants is indicated in parenthesis. Black lines indicate the mean ± standard deviation for each axis. D Clustering of normalised cis-QTL effects for 3237 QTLs colocalizing with GWAS trait variants and with measured effects for all types of QTL-associations. Six distinct clusters are labelled. E Enrichment of QTLs upstream, within or downstream of associated genes (left panel) and enrichment within annotated genomic regions (right panel) for cis-QTLs of each cluster compared to cis-QTLs of other clusters. Intron-edges include 100 bps at intron starts and ends. *, p < 0.05, **, p < 0.01, ***, p < 0.0001, calculated using two-sided Fisher’s exact test. F Average number of exons per annotated transcript (left panel) and average 3’ UTR length (right panel) of genes associated with top cis-QTLs in different clusters (indicated by colour code from D). Boxes indicate the interquartile range of the data (second and third quartile) with a line at the median. Whiskers extend to the farthest data point lying within 1.5× the interquartile range from the box. *, p = 0.011, **, p = 0.0014, calculated using two-sided Ranksum test compared to genes with cis-QTLs in other clusters. The number of genes included in each box are n = 290, 174, 671, 87, 297 and 962.