Table 2. Subgroup analyses and Meta-regression results.
| Variables | No. of models | Sensitivity |
Specificity |
PLR |
NLR |
DOR |
AUC | Meta regressionP | |||||
| Pooled (95%CI) | I² | Pooled (95%CI) | I² | Pooled (95%CI) | I² | Pooled (95%CI) | I² | Pooled (95%CI) | I² | ||||
| Region | 0.00 | ||||||||||||
| Asian | 28 | 0.94 (0.92, 0.96) | 92.62% | 0.91 (0.87, 0.94) | 94.06% | 10.39 (7.38, 14.63) | 93.74% | 0.06 (0.04, 0.09) | 93.52% | 168.82 (90.82, 313.80) | 100% | 0.97 | |
| Western | 23 | 0.82 (0.70, 0.89) | 93.54% | 0.88 (0.85, 0.91) | 75.45% | 6.84 (4.81, 9.70) | 76.38% | 0.21 (0.12, 0.36) | 92.69% | 33.08 (13.85, 79.05) | 100% | 0.92 | |
| Method | 0.00 | ||||||||||||
| ML | 27 | 0.84 (0.76, 0.90) | 94.23% | 0.87 (0.84, 0.90) | 88.56% | 6.67 (5.05, 8.79) | 87.11% | 0.18 (0.11, 0.29) | 94.54% | 36.98 (19.30, 70.86) | 100% | 0.92 | |
| DL | 24 | 0.95 (0.91, 0.97) | 94.71% | 0.92 (0.89, 0.94) | 92.60% | 11.94 (8.23, 17.32) | 92.05% | 0.06 (0.03, 0.10) | 95.12% | 209.55 (91.56, 4779.59) | 100% | 0.98 | |
| Outcome | 0.06 | ||||||||||||
| OAG | 39 | 0.91 (0.86, 0.95) | 95.38% | 0.91 (0.89, 0.93) | 85.87% | 10.23 (7.73, 13.55) | 86.58% | 0.10 (0.06, 0.16) | 95.89% | 107.50 (52.10, 221.80) | 100% | 0.96 | |
| Glaucoma | 12 | 0.88 (0.83, 0.92) | 88.39% | 0.84 (0.79, 0.89) | 88.18% | 5.62 (4.09, 7.74) | 85.38% | 0.14 (0.09, 0.21) | 89.44% | 40.55 (21.54, 76.32) | 100% | 0.93 | |
| Device | |||||||||||||
| Topcon 3D OCT | 7 | 0.92 (0.85, 0.96) | 89.58% | 0.90 (0.87, 0.93) | 71.39% | 9.59 (6.89, 13.36) | 50.19% | 0.09 (0.05, 0.17) | 89.10% | 108.97 (52.58, 225.86) | 100% | 0.95 | 0.58 |
| Heidelberg Spectralis OCT | 10 | 0.94 (0.91, 0.96) | 93.56% | 0.94 (0.89, 0.97) | 96.22% | 15.72 (8.66, 28.53) | 95.81% | 0.06 (0.04, 0.10) | 95.06% | 243.19 (91.31, 647.67) | 100% | 0.98 | 0.02 |
| Cirrus ZEISS OCT | 30 | 0.85 (0.77, 0.90) | 93.78% | 0.87 (0.83, 0.90) | 86.96% | 6.38 (4.78, 8.52) | 83.98% | 0.17 (0.11, 0.27) | 93.84% | 36.70 (19.21, 70.13) | 100% | 0.92 | 0.00 |
DL: Deep learning; ML: Machine learning; OAG: Open angle glaucoma; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; DOR: Diagnostic odds ratio; AUC: Area under curve.