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. 2024 Apr 23;18:1368552. doi: 10.3389/fnins.2024.1368552

Figure 2.

Figure 2

Probucol has no effect on anxiety and depression-like behaviors in HFD-fed mice. (A–G) Performance of mice in the elevated plus maze test. The data are expressed as individual values with median ± 95% CI (n = 11 or 12 mice for each group). Head dipping, Kruskal-Wallis test (p = 0.0044), followed by Dunn’s multiple comparisons test. Time in open arms, Kruskal-Wallis test (p = 0.0154), followed by Dunn’s multiple comparisons test. Distance in open arms, Kruskal-Wallis test (p = 0.0137), followed by Dunn’s multiple comparisons test. Entries in open arms, Kruskal-Wallis test (p = 0.0278), followed by Dunn’s multiple comparisons test. Entries in closed arms, Kruskal-Wallis test (p = 0.4304). Time in closed arms, ordinary one-way ANOVA (p = 0.1647). Distance in closed arms, ordinary one-way ANOVA (p = 0.0173), followed by Tukey’s multiple comparison. (H,I) Performance of mice in the forced swim test. The immobility duration and global activity are presented as individual values with median ± 95% CI (n = 11 or 12 mice for each group). Immobility duration, Kruskal-Wallis test (p = 0.0155), followed by Dunn’s multiple comparisons test. Global activity, Kruskal-Wallis test (p = 0.0127), followed by Dunn’s multiple comparisons test. p < 0.05 was indicative of statistical significance.