Table 1.
Preliminary Trials to Assess the Solubility of 0.1% w/v Dexamethasone at Various P40S and P80 Ratios
| Ratio of P40S/P80 | Clarity | Particle size (nm) (mean±SD) | Chi square values |
|---|---|---|---|
| 1:9 | Hazy | — | — |
| 2:8 | Hazy | — | — |
| 3:7 | Hazy | — | — |
| 4:6 | Hazy | — | — |
| 5:5 | Hazy | — | — |
| 6:4 | Clear | 18.4±11.8 | 12.4 |
| 7:3a | Clear | 13.7±4.7 | 6.6 |
| 8:2 | Clear | 13.0±4.8 | 7.5 |
| 9:1 | Clear | 17.2±9.9 | 17.9 |
Clear solution indicates complete drug solubility in the mixed nanomicellar core. Hazy solution indicates incomplete drug solubility.
a
The composition of P40S/P80=7/3 by weight that was considered for later studies.
P40S, polyoxyl 40 stearate; P80, polysorbate 80; SD, standard deviation.