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. Author manuscript; available in PMC: 2024 May 7.
Published in final edited form as: J Immunol. 2022 Feb 18;208(6):1406–1416. doi: 10.4049/jimmunol.2100900

Figure 4. BCG/αIL-10R1 administration increases antigen specific Th1 and Th17 cytokine responses.

Figure 4.

WT mice were immunized with BCG/αIL-10R1 or BCG/IgG1 (A-C). IL-10 −/− CBA/J mice were vaccinated with saline or BCG (D-F). Mice were euthanized at 7 weeks post vaccination and lung mononuclear cells ex-vivo stimulated without (medium) or with CFP for 48 hrs. Culture supernatant were analyzed for the production of IFN-γ (A, D), TNF-α (B, E) and IL-17 (C, F) respectively. Data represents the mean ± SE of 3 to 5 mice in each group. Student’s t test was performed to determine statistical significance between the response to CFP of BCG/IgG1 and BCG/αIL-10R1 experimental groups (A-C) or IL-10 −/− saline and BCG experimental groups (D-F). *P<0.05.