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. Author manuscript; available in PMC: 2024 May 7.
Published in final edited form as: J Immunol. 2022 Feb 18;208(6):1406–1416. doi: 10.4049/jimmunol.2100900

Figure 7. BCG/ αIL-10R1 administration enhances central memory T-cell responses in lung of M.tb infected mice.

Figure 7.

WT mice were subcutaneously immunized with saline, BCG/αIL-10R1 or BCG/IgG1. 7 weeks later, mice were challenged with M.tb and euthanized at the 4- (A-H) and 8-week (I-P) post infection. Figure represents absolute number and cellular frequency of (A, I & Q, Y) CD4+, (B,J & R, Z) CD4+ CD44hi, C, K & S, AA) CD4+CD44hiCD62L+CCR7+ central memory, (D,L &T,AB) CD4+CD44hiCD62L−CCR7− effector memory, (E,M & U,AC) CD8+, (F,N & V, AD) CD8+CD44hi, (G,O & W, AE) CD8+CD44hiCD62L+CCR7+ central memory, (H,P & X,AF) CD8+CD44hiCD62L−CCR7− effector memory. Data are the mean ± SE of one of the two independent experiment with 3 to 5 mice in each group. Student’s t test was performed to determine the statistical significance between BCG/αIL-10R1 or BCG/IgG1 experimental groups. *P<0.05; **P<0.01.