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. 2024 May 7;12:73. doi: 10.1186/s40478-024-01786-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Representative confocal microscopy images of microglia in close proximity to AD-plaques in mixed DLB cases. Localization of pSer129-syn (green), Aβ (yellow), p-tau (red) and Iba1+ (purple) microglia in neuritic and classic cored plaques in the CA1, EntC and TC regions demonstrated with confocal microscopy. a-e Many large clustered and amoeboid Iba1-positive microglia with short, thick processes in the neuritic plaque in the CA1 within and in closer proximity to neuritic p-tau and p-syn accumulation. f-j Another example of rod-like and amoeboid Iba1-positive microglia in a neuritic plaque in the CA1. k-o Amoeboid and clustered microglia within and surrounding a classic-cored plaque in the EntC with neuritic p-tau and p-syn pathology. p-t Reactive microglial cell with large cell soma and thick processes within a classic-cored plaque with mainly Aβ pathology present in the TC. The scale bars in a, f, k, p are identical for all images in one row and represent 20 μm in all