Fig. 6.

Variants of APOEε4 and GBA1 genotype influenced the level of Aβ and p-tau pathology. Immunopositivity of α-syn, Aβ, p-tau, Iba1, HLA-DR, CD68 and GFAP is visualized in a scatter plot with box of mean pathology load over all measured brain regions [SD]. a Aβ load increased with the number of APOEε4 alleles and was significantly higher in heterozygous and homozygous than non-carriers. Microglial load was higher in homozygous than in heterozygous APOEε4 or than in non-carriers. b No differences in pathology or micro- or astroglial load were observed between different frequencies of HLA-DRB1*04 alleles. c Pathogenic GBA1 carriers had a higher Aβ and p-tau load than non-carriers. A linear mixed model analysis with correction for age of death and gender was performed to compare genotypes. * p < 0.05, ** p < 0.01, *** p < 0.001