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. 2024 May 7;23:91. doi: 10.1186/s12943-024-01998-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circ_PPAPDC1A expression is elevated in Osimertinib resistance NSCLC tissues and cells. A Successful establishment of Osimertinib resistance cells, named as PC9/OR and HCC827/OR. The transfection efficiency was assessed by RT-qPCR. B RT-qPCR analysis of circ_100696 expression in PC9/OR and HCC827/OR cells. circRNA_100696 expression levels were normalized to GAPDH. C, D Successful establishment of circRNA_100696 overexpression and knockdown cellular models. circ_100696 overexpression and knockdown lentiviral vectors were subsequently stably transfected them into PC9/OR and HCC827/OR cells, as well as their parental PC9 and HCC827 cells. n = 3. *P < 0.05, **P < 0.01, na: no statistical significance. Osimertinib Sensitive; OR: Osimertinib Resistance. RT-qPCR, reverse transcription-quantitative PCR. circ_100696: circ_PPAPDC1A