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. 2024 May 7;23:91. doi: 10.1186/s12943-024-01998-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — circ_PPAPDC1A decreased Osimertinib sensitivity of NSCLC and suppresses the cell malignant behaviors in vitro. A Cell counting kit-8 (CCK8) assay was conducted to determine the IC50 value of Osimertinib. B Soft agar colony assay was employed to assess colony formation ability. C EdU assay was performed to evaluate DNA synthesis ability. D Transwell chamber assay was performed to analyze cell invasion ability. D Cell scratch assay was carried out to examine Cell migration ability. F and Annexin V-FITC/PI assay was performed to investigate cell apoptosis. n = 3. *P < 0.05, **P < 0.01. Osimertinib Sensitive; OR: Osimertinib Resistance. RT-qPCR, reverse transcription-quantitative PCR. circ_100696: circ_PPAPDC1A